The Xativa Hub is an Australian patient access gateway and an information hub for GPs and specialists to find out more about current research and treatment products available in Australia.
iX Syrinx is developing a range of sublingual wafers containing cannabidiol (CBD) by using its patented sublingual delivery technology, WaferiX®.
iX is currently evaluating these CBD sublingual wafers for use in the treatment of certain conditions.
Background on Medicinal Cannabis
Cannabis has a long and colourful history.
It is a plant of the Cannabaceae family and its medicinal properties have been known for millennia¹.
Cannabis was first thought to have originated from Central Asia and was used by many ancient societies.
In fact, indications for therapeutic use of cannabis were mentioned in the texts of the Indian Hindus, Assyrians, Greeks and Romans. Cannabis was described to have helped alleviate and treat many health ailments, including pain, depression, inflammation, appetite loss and asthma related problems et cetera.
How Does Medicinal Cannabis Work?
The Cannabis plant contains two of the most prominent cannabinoids;
Cannabidiol (CBD) and Delta-9-Tetrahydrocannabinol (THC).
Through the Endocannabinoid System in our body, CBD and THC interact to have various effects.
| CBD | THC |
|---|---|
| Non-intoxicating | Intoxicating |
| Anti-inflammatory and reduces pain | Anti-inflammatory and reduces pain |
| May reduce anxiety | May improve appetite |
| Anticonvulsant | Potentially reduces nausea |
| Regulate THC effects | May help with insomnia |
Image adapted from Partow, Cyrus 20194 and elitecme.com
The Endocannabinoid System
The endocannabinoid system (ECS) is a complex cell-signalling system found throughout our body³.
It consists of three key components, including:
Endocannabinoids
- Molecules created by our body
- Help keep internal functions running smoothly
Receptors
- Receptors found throughout our body
- Two key receptors
- CB1 - mainly found in central nervous system
- CB2 - mainly found in peripheral nervous system
- Endocannabinoids bind to either receptor & effects depend on where the receptor is located
Enzymes
Responsible for breaking down endocannabinoids once they have served their function
The endocannabinoid system plays a critical role in balancing many processes in our body, including immune response, appetite, sleep, et cetera.